Myelodysplastic syndromes. Clinical and biological advances
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چکیده
منابع مشابه
Myelodysplastic Syndromes Myelodysplastic syndromes: recent advances
Etiology of myelodysplastic syndromes The models for the development of sporadic MDS suggest the role of cumulative environmental exposures in genetically predisposed individuals. There is increasing evidence for a complex genetic predisposition to MDS involving naturally occurring DNA polymorphisms in genes that mediate DNA repair and metabolize environmental carcinogens.3 Large epidemiologic ...
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of risk. This importance is particularly stressed if the prognostic variability and aggressive nature of the currently available curative treatment options is taken into account, especially when considering the advanced age of the majority of patients. Although the French-American-British (FAB) classification has been relatively effective for categorizing MDS patients since 1982,1 its limitatio...
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Myelodysplastic syndromes (MDS) are a heterogeneous group of chronic hematological malignancies characterized by dysplasia, ineffective hematopoiesis and a variable risk of progression to acute myeloid leukemia. Sequencing of MDS genomes has identified mutations in genes implicated in RNA splicing, DNA modification, chromatin regulation, and cell signaling. We sequenced 111 genes across 738 pat...
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A Review of Selected Presentations From the 49th American Society of Hematology Annual Meeting and Exposition, December 8-11, 2007, Atlanta, Georgia.
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ژورنال
عنوان ژورنال: Bone Marrow Transplantation
سال: 2006
ISSN: 0268-3369,1476-5365
DOI: 10.1038/sj.bmt.1705337